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UAB Brain Tumor Developmental Research Program

   The UAB Brain Tumor SPORE grant (P50 CA 097247) offers up to 3 Developmental Research Awards annually to support 1- or 2-year projects that seek to develop preliminary data to support a larger grant application to an extramural funding agency.  The primary focus of the research is translational, and may include preclinical investigations for any therapeutic agent, diagnostic test, epidemiologic study, biomarker development for detection, or correlative biologic study.  Since initiation of funding in September 2002, the UAB Brain Tumor SPORE has awarded 12 Developmental Research Grants.  A brief description of each funded project follows:

Twelve Developmental Projects have been funded through the UAB Brain Tumor SPORE.

Dale J. Benos, Ph.D. - Physiology of ASIC2 in high grade gliomas

Jeffrey A. Engler, Ph.D. - Brain tumor-Specific Cell Surface Molecules

Charles S. Cobbs, M.D. & Matthias H. Kraus, M.D. - Role of human cytomegalovirus (HCMV) in activation of the ligand-dependent oncogenic phenotype of EGFR in malignant glioma

Hongju Wu, Ph.D. - Transcytosis-targeted Adenoviral Vector for Brain Cancer

Corinne E. Griguer, Ph.D. - Preclinical Studies with a Novel Cytostatic Agent, OMX-2

Martin Johnson, Ph.D. - Gene Expression Analysis of Primary Glioblastoma Multiforme (GBM)

Sergey Kaliberov, Ph.D. - Therapy of Human Glioma Using CRAd Encoding the MDA-7 gene (CRAdSK-1) alone and in combination with ionizing radiation

Kevin A. Cassady, M.D. - Chimeric HSV-HCMV recombinant vectors for Glioma Therapy

John B. Fiveash, M.D. - Optimization of Death Receptor Therapy for Malignant Glioma

Lawrence S. Lamb, Jr., R.N., Ph.D. - Cellular Therapy for Malignant Gliomas

Cheryl A. Palmer, M.D. - Molecular Neuropathology Component for the Brain SPORE

Mona N. Fouad, M.D. - Patient Navigator Program for the Brain Tumor SPORE